Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737524 | 0.90 | SYK (0.67) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL14737771 | 0.87 | SYK (0.65) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL14737226 | 0.85 | SYK (0.80) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL14743763 | 0.82 | SYK (0.61) | SYKCYP2C9CYP2D6JAK2JAK1 | |
| SCHEMBL14737556 | 0.82 | SYK (0.67) | SYKCYP2C9CYP2D6JAK2JAK1 | |
| SCHEMBL14737399 | 0.81 | SYK (0.59) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL14738037 | 0.80 | JAK2 (0.63) | SYKCYP2C9CYP2D6JAK2JAK1 | |
| SCHEMBL14737260 | 0.80 | SYK (0.83) | SYKKCNH2CYP2C9CYP2D6JAK2 | |
| SCHEMBL14738355 | 0.79 | JAK2 (0.60) | SYKCYP2C9CYP2D6JAK2JAK1 | |
| SCHEMBL14751336 | 0.79 | SYK (0.64) | SYKKCNH2CYP2C9CYP2D6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |