Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.56 |
| ▸ | FPR2 | P25090 | 5/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14743527 | 1.00 | SCN9A (0.56) | SCN9AFPR2PLA2G2A | |
| SCHEMBL14743168 | 0.83 | SCN9A (0.68) | SCN9AFPR2 | |
| SCHEMBL14744111 | 0.82 | SCN9A (0.72) | SCN9AFPR2 | |
| SCHEMBL14744112 | 0.82 | SCN9A (0.72) | SCN9AFPR2 | |
| SCHEMBL14743717 | 0.81 | SCN9A (0.68) | SCN9AFPR2 | |
| SCHEMBL14743206 | 0.81 | SCN9A (0.68) | SCN9AFPR2 | |
| SCHEMBL19138164 | 0.80 | SCN9A (0.63) | SCN9AFPR2 | |
| SCHEMBL14743899 | 0.80 | SCN9A (0.68) | SCN9AFPR2 | |
| SCHEMBL19072263 | 0.79 | SCN9A (0.53) | SCN9AFPR2PLA2G2A | |
| SCHEMBL16012458 | 0.78 | SCN9A (0.70) | SCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964639-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | Purdue Pharma LP (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014135955-A1 | PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2014-09-12 | — | — | WO | disclosed |
| WO-2013030665-A1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2013-03-07 | — | — | WO | disclosed |