Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28132506 | 0.79 | MAPK1 (0.41) | JAK3JAK2JAK1 | |
| SCHEMBL653402 | 0.77 | JAK3 (0.41) | JAK3KDM4EALDH1A1JAK2JAK1 | |
| SCHEMBL29936423 | 0.75 | JAK3 (0.47) | JAK3ROCK2ROCK1JAK2JAK1 | |
| SCHEMBL28133335 | 0.75 | JAK3 (0.51) | JAK3KDM4EALDH1A1JAK2JAK1 | |
| SCHEMBL27905682 | 0.74 | JAK3 (0.52) | JAK3KDM4EALDH1A1CNR1CNR2 | |
| SCHEMBL29936557 | 0.74 | JAK3 (0.52) | JAK3 | |
| SCHEMBL1369433 | 0.74 | JAK3 (0.65) | JAK3ROCK2ROCK1JAK2JAK1 | |
| SCHEMBL18720838 | 0.72 | CHRM1 (0.50) | JAK3JAK2JAK1 | |
| SCHEMBL16764992 | 0.71 | CNR2 (0.60) | JAK3KDM4EALDH1A1CNR1CNR2 | |
| SCHEMBL2277209 | 0.71 | MAPK1 (0.48) | EGLN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |