Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.30 |
| ▸ | MERTK | Q12866 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14736678 | 0.83 | MAPT (0.43) | PIK3CD | |
| SCHEMBL14736001 | 0.83 | PIK3CD (0.44) | PIK3CD | |
| SCHEMBL14742470 | 0.79 | PIK3CD (0.35) | PIK3CD | |
| SCHEMBL14753976 | 0.78 | PIK3CD (0.41) | PIK3CDAXLMERTK | |
| SCHEMBL14736186 | 0.78 | PIK3CD (0.41) | PIK3CDAXLMERTK | |
| SCHEMBL14736738 | 0.76 | PIK3CD (0.41) | PIK3CD | |
| SCHEMBL14736290 | 0.75 | PIK3CD (0.42) | PIK3CDAXLMERTK | |
| SCHEMBL14736911 | 0.74 | MAPT (0.46) | PIK3CD | |
| SCHEMBL14736413 | 0.74 | PIK3CD (0.44) | PIK3CD | |
| SCHEMBL9928833 | 0.73 | PIK3CD (0.43) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | disclosed |