Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14746784 | 0.94 | SYK (0.40) | SYKADORA2AKDM4EALDH1A1CYP2C9 | |
| SCHEMBL14737201 | 0.92 | SYK (0.41) | SYKADORA2AJAK2JAK1JAK3 | |
| SCHEMBL14738404 | 0.90 | SYK (0.51) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL14746431 | 0.87 | KDM4C (0.38) | SYKJAK2JAK1JAK3KDM4E | |
| SCHEMBL14738009 | 0.86 | SYK (0.40) | SYKCYP2C9SCN9APTGER4CYP2D6 | |
| SCHEMBL18524438 | 0.84 | SYK (0.42) | SYKADORA2AJAK2JAK1JAK3 | |
| SCHEMBL14743711 | 0.83 | SYK (0.54) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL14738001 | 0.82 | SYK (0.51) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL18524434 | 0.82 | SYK (0.39) | SYKKDM4ECYP2C9CYP2D6 | |
| SCHEMBL14737596 | 0.82 | SYK (0.42) | SYKJAK2JAK1JAK3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |