Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.73 |
| ▸ | AXL | P30530 | 2/20 | 0.69 |
| ▸ | MERTK | Q12866 | 2/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29836206 | 1.00 | PIK3CD (0.73) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL14736404 | 0.92 | AXL (0.70) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL14735963 | 0.92 | PIK3CD (0.78) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL29836208 | 0.92 | PIK3CD (0.78) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL14736886 | 0.92 | PIK3CD (0.71) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL14736415 | 0.92 | PIK3CD (0.71) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL29836054 | 0.91 | PIK3CD (0.76) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL17458638 | 0.91 | PIK3CD (0.76) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL29836121 | 0.91 | PIK3CD (0.76) | PIK3CDAXLMERTKKCNH2 | |
| SCHEMBL17458645 | 0.91 | PIK3CD (0.70) | PIK3CDAXLMERTKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2751109-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2014-07-09 | — | — | EP | claimed |
| WO-2013033569-A1 | HETEROCYCLYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2013-03-07 | — | — | WO | claimed |