Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738378 | 0.91 | SYK (0.40) | SYKKDM4EALDH1A1JAK2JAK1 | |
| SCHEMBL14737146 | 0.85 | SYK (0.42) | SYKKDM4CJAK2JAK1JAK3 | |
| SCHEMBL14739146 | 0.83 | SYK (0.41) | SYKKDM4EALDH1A1CYP2C9CYP2D6 | |
| SCHEMBL14746730 | 0.80 | SYK (0.39) | SYKL3MBTL1CYP2C9CYP2D6 | |
| SCHEMBL14751644 | 0.79 | SYK (0.44) | SYKKDM4EALDH1A1JAK2JAK1 | |
| SCHEMBL14738174 | 0.78 | SYK (0.43) | SYKKDM4EALDH1A1JAK2JAK1 | |
| SCHEMBL14737299 | 0.76 | SYK (0.41) | SYKL3MBTL1CYP2C9CYP2D6 | |
| SCHEMBL14737166 | 0.75 | SYK (0.49) | SYKCYP2C9CYP2D6 | |
| SCHEMBL14743763 | 0.74 | SYK (0.61) | SYKJAK2JAK1JAK3CYP2C9 | |
| SCHEMBL14737942 | 0.74 | SYK (0.39) | SYKJAK2JAK1JAK3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |