Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14746874 | 0.88 | SYK (0.43) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14747010 | 0.87 | SYK (0.46) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14737677 | 0.86 | SYK (0.47) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14746916 | 0.86 | SYK (0.43) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14737669 | 0.85 | SYK (0.60) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14747035 | 0.85 | SYK (0.46) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14737345 | 0.85 | SYK (0.46) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14751360 | 0.85 | SYK (0.46) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14751159 | 0.85 | SYK (0.45) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14746869 | 0.85 | SYK (0.42) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |