Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.54 |
| ▸ | JAK2 | O60674 | 10/20 | 0.44 |
| ▸ | JAK1 | P23458 | 10/20 | 0.44 |
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14751247 | 1.00 | SYK (0.54) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738185 | 0.94 | SYK (0.60) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14747031 | 0.92 | SYK (0.62) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14747019 | 0.92 | SYK (0.62) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14746988 | 0.91 | SYK (0.54) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14746977 | 0.91 | SYK (0.54) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14738623 | 0.91 | SYK (0.54) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14746950 | 0.90 | SYK (0.52) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14746922 | 0.90 | SYK (0.52) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14751250 | 0.90 | SYK (0.54) | SYKJAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853219-B2 | Compounds and compositions for cognition-enhancement, methods of making, and methods of treating | NEUROSOLIS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |