Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | JAK1 | P23458 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738072 | 0.85 | SYK (0.66) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14751509 | 0.83 | SYK (0.70) | SYKCYP2C9JAK2JAK1JAK3 | |
| Trifluoroacetic Acid SCHEMBL14737762 | 0.82 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14746443 | 0.81 | SYK (0.79) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14738965 | 0.81 | SYK (0.65) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14755209 | 0.81 | SYK (0.78) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14755189 | 0.81 | SYK (0.78) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14738724 | 0.80 | SYK (0.72) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14746738 | 0.79 | SYK (0.76) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL14738210 | 0.79 | SYK (1.00) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |