Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | FABP3 | P05413 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14747227 | 0.91 | CHRM1 (0.68) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL3234551 | 0.91 | CHRM1 (0.67) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL3234278 | 0.88 | CHRM1 (0.64) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL3234394 | 0.88 | CHRM1 (0.86) | CHRM1MAPTLMNATP53 | |
| SCHEMBL3228651 | 0.88 | CHRM1 (0.64) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL3233806 | 0.88 | CHRM1 (0.64) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL3234585 | 0.87 | CHRM1 (0.63) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL2488647 | 0.87 | CHRM1 (0.76) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL3233931 | 0.87 | CHRM1 (0.62) | CHRM1NPC1RAB9ANOD2MAPT | |
| SCHEMBL3230348 | 0.87 | CHRM1 (0.72) | CHRM1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |