Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 9/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 3/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.31 |
| ▸ | F9 | P00740 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | FRK | P42685 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.31 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722959 | 0.87 | TYK2 (0.33) | TYK2PDE4DGAASMN1; SMN2ATR | |
| SCHEMBL13062521 | 0.87 | ATR (0.35) | TYK2PDE4DATRF10LCK | |
| SCHEMBL13013466 | 0.81 | TYK2 (0.42) | TYK2PDE4D | |
| SCHEMBL3730771 | 0.81 | TYK2 (0.42) | TYK2PDE4D | |
| SCHEMBL3730769 | 0.81 | TYK2 (0.42) | TYK2PDE4D | |
| SCHEMBL3719701 | 0.80 | TYK2 (0.43) | TYK2PDE4D | |
| SCHEMBL13013461 | 0.80 | TYK2 (0.43) | TYK2PDE4D | |
| SCHEMBL3719712 | 0.80 | TYK2 (0.43) | TYK2PDE4D | |
| SCHEMBL3720955 | 0.74 | TYK2 (0.38) | TYK2PDE4DATRF10 | |
| SCHEMBL3719904 | 0.74 | MEN1 (0.40) | TYK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8389527-B2 | Substituted imidazopyridazines useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-03-05 | — | — | US | disclosed |