Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 13/20 | 0.67 |
| ▸ | CDK9 | P50750 | 12/20 | 0.67 |
| ▸ | BCL6 | P41182 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716910 | 0.88 | CDK7 (0.67) | CDK7CDK9ALKMETINSR | |
| SCHEMBL12312014 | 0.84 | CDK7 (0.71) | CDK7CDK9ALKMETINSR | |
| SCHEMBL12312023 | 0.80 | CDK7 (0.66) | CDK7CDK9ALKMETINSR | |
| SCHEMBL12862540 | 0.80 | CDK7 (0.66) | CDK7CDK9ALKMETINSR | |
| Hydrochloric Acid SCHEMBL30817651 | 0.79 | CDK7 (0.64) | CDK7CDK9ALKMETINSR | |
| SCHEMBL12862529 | 0.78 | ZAP70 (0.51) | CDK7CDK9BCL6ALKMET | |
| SCHEMBL31251230 | 0.76 | CDK7 (0.53) | CDK7CDK9ALKMETIGF1R | |
| SCHEMBL29214356 | 0.76 | CDK7 (0.76) | CDK7CDK9ALKMETAURKA | |
| SCHEMBL29214353 | 0.76 | CDK7 (0.76) | CDK7CDK9ALKMETAURKA | |
| SCHEMBL20232208 | 0.72 | BCL6 (0.58) | CDK9BCL6ALKAURKAIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |