Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.79 |
| ▸ | MTOR | P42345 | 5/20 | 0.71 |
| ▸ | AKT1 | P31749 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089142 | 0.90 | PIK3CA (0.81) | PIK3CAMTORAKT1 | |
| SCHEMBL14747992 | 0.89 | PIK3CA (0.82) | PIK3CAMTOR | |
| SCHEMBL14747993 | 0.89 | PIK3CA (0.85) | PIK3CAMTORAKT1 | |
| SCHEMBL1619559 | 0.89 | PIK3CA (1.00) | PIK3CAMTORAKT1 | |
| SCHEMBL1621837 | 0.88 | PIK3CA (1.00) | PIK3CAMTORAKT1 | |
| SCHEMBL14747994 | 0.84 | PIK3CA (0.78) | PIK3CAMTOR | |
| SCHEMBL1619564 | 0.83 | PIK3CA (0.89) | PIK3CAMTORAKT1 | |
| SCHEMBL8090821 | 0.83 | PIK3CA (0.81) | PIK3CAMTORAKT1 | |
| SCHEMBL1621714 | 0.83 | PIK3CA (1.00) | PIK3CAMTORAKT1 | |
| SCHEMBL1619381 | 0.81 | PIK3CA (1.00) | PIK3CAMTORAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183232-B1 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2013-03-06 | — | — | EP | disclosed |