Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.56 |
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 12/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13013944 | 0.89 | HTR2A (0.56) | HTR2ADRD2HTR1AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL1970211 | 0.88 | HTR2A (0.55) | HTR2ADRD2HTR1AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL1970209 | 0.88 | HTR2A (0.55) | HTR2ADRD2HTR1AHTR7DRD3 | |
| SCHEMBL14748241 | 0.87 | HTR2A (0.52) | HTR2AHTR1ADRD3 | |
| SCHEMBL14748258 | 0.87 | HTR2A (0.51) | HTR2ADRD2HTR1AHTR7DRD3 | |
| SCHEMBL22302917 | 0.85 | HTR2A (0.53) | HTR2ADRD2HTR1AHTR7DRD3 | |
| SCHEMBL12631894 | 0.84 | HTR2A (0.54) | HTR2ADRD2HTR1AHTR7 | |
| SCHEMBL12631926 | 0.84 | HTR2A (0.54) | HTR2ADRD2HTR1AHTR7 | |
| SCHEMBL22303281 | 0.84 | HTR2A (0.54) | HTR2ADRD2HTR1AHTR7DRD3 | |
| SCHEMBL21026108 | 0.82 | DRD3 (0.61) | HTR2ADRD2HTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |