Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822158 | 0.91 | PIK3CA (0.73) | PIK3CAMTORPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1822331 | 0.80 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL1821814 | 0.76 | PIK3CA (0.86) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL1820803 | 0.75 | PIK3CA (0.81) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL14096751 | 0.74 | PIK3CA (0.75) | PIK3CAMTORPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1820302 | 0.73 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL2469687 | 0.73 | PIK3CA (0.79) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL1820834 | 0.72 | PIK3CA (0.75) | PIK3CAMTORPIK3CBPIK3CG | |
| SCHEMBL1821190 | 0.71 | PIK3CA (0.81) | PIK3CAMTORPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1820209 | 0.71 | PIK3CA (1.00) | PIK3CAMTORPIK3CBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316831-B1 | 2-(morpholin-4-yl)pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |