Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.38 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | JAK3 | P52333 | 5/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14751019 | 1.00 | SYK (0.42) | SYKCNR1CNR2JAK2JAK1 | |
| SCHEMBL14738711 | 0.88 | CNR1 (0.41) | SYKCNR1CNR2JAK2JAK1 | |
| SCHEMBL14738713 | 0.88 | CNR1 (0.41) | SYKCNR1CNR2JAK2JAK1 | |
| SCHEMBL14746989 | 0.87 | SYK (0.42) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14746993 | 0.87 | SYK (0.45) | SYKCNR2JAK2JAK1JAK3 | |
| SCHEMBL14746951 | 0.87 | SYK (0.45) | SYKCNR2JAK2JAK1JAK3 | |
| SCHEMBL14746957 | 0.87 | SYK (0.47) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14750178 | 0.86 | SYK (0.45) | SYKCNR2JAK2JAK1JAK3 | |
| SCHEMBL14746980 | 0.86 | SYK (0.46) | SYKJAK2JAK1JAK3TYK2 | |
| SCHEMBL14746959 | 0.86 | SYK (0.44) | SYKCNR2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |