Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14739279 | 0.96 | SYK (0.60) | SYKKCNH2CYP2C9CYP2D6DGAT1 | |
| SCHEMBL14737183 | 0.94 | SYK (0.70) | SYKKCNH2CYP2C9CYP2D6 | |
| SCHEMBL14737668 | 0.92 | SYK (0.58) | SYKKCNH2CYP2C9CYP2D6DGAT1 | |
| SCHEMBL14737822 | 0.92 | SYK (0.70) | SYKKCNH2CYP2C9CYP2D6 | |
| SCHEMBL14737571 | 0.91 | SYK (0.57) | SYKKCNH2CYP2C9CYP2D6DGAT1 | |
| SCHEMBL14737101 | 0.90 | SYK (0.56) | SYKKCNH2CYP2C9CYP2D6DGAT1 | |
| SCHEMBL14738744 | 0.90 | SYK (0.56) | SYKKCNH2CYP2C9CYP2D6DGAT1 | |
| SCHEMBL14737542 | 0.90 | SYK (0.58) | SYKKCNH2CYP2C9CYP2D6DGAT1 | |
| SCHEMBL14737786 | 0.90 | SYK (0.68) | SYKKCNH2CYP2C9CYP2D6DGAT1 | |
| SCHEMBL14737428 | 0.90 | SYK (0.56) | SYKKCNH2CYP2C9CYP2D6DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013030138-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-07 | — | — | WO | disclosed |