SCHEMBL14756015

SCHEMBL14756015

Cc1sc2c(c1C)C(c1ccc(C(C)C)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 18/20 0.84
BRDT Q58F21 6/20 0.84
BRD2 P25440 3/20 0.84
BRD3 Q15059 3/20 0.84
CREBBP Q92793 2/20 0.84
HDAC3 O15379 1/20 0.84
JAK2 O60674 1/20 0.84
BRD1 O95696 1/20 0.84
CCL2 P13500 1/20 0.84
HDAC4 P56524 1/20 0.84
EP300 Q09472 1/20 0.84
HDAC1 Q13547 1/20 0.84
DNER Q8NFT8 1/20 0.84
HDAC7 Q8WUI4 1/20 0.84
HDAC2 Q92769 1/20 0.84
HDAC10 Q969S8 1/20 0.84
HDAC11 Q96DB2 1/20 0.84
HDAC8 Q9BY41 1/20 0.84
HDAC6 Q9UBN7 1/20 0.84
HDAC9 Q9UKV0 1/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25514131 0.91 BRD4 (0.84) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL21349525 0.91 BRD4 (0.84) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL881208 0.91 BRD4 (1.00) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL881473 0.91 BRD4 (1.00) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL881227 0.91 BRD4 (1.00) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL21320191 0.91 BRD4 (0.87) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL15984904 0.91 BRD4 (0.87) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL23660571 0.90 BRD4 (0.84) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL22973254 0.90 BRD4 (0.87) BRD4BRDTBRD2BRD3CREBBP
SCHEMBL23660513 0.90 BRD4 (0.84) BRD4BRDTBRD2BRD3CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159554-A1 COMPOUND WITH ANTICANCER ACTIVITY KYOWA KIRIN CO., LTD. (JP) 2023-05-25 US disclosed
US-20230159554-A1 COMPOUND WITH ANTICANCER ACTIVITY KYOWA KIRIN CO., LTD. (JP) 2023-05-25 US disclosed
WO-2015081280-A1 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION COFERON, INC. (US) 2015-06-04 WO disclosed
WO-2015081284-A1 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME COFERON, INC. (US) 2015-06-04 WO disclosed
US-20140243286-A1 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME COFERON, INC. (US) 2014-08-28 US disclosed
US-20140243322-A1 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME COFERON, INC. (US) 2014-08-28 US disclosed
US-20140243321-A1 BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS, AND METHODS OF USING SAME COFERON, INC. (US) 2014-08-28 US disclosed
WO-2013033268-A2 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME COFERON, INC. (US) 2013-03-07 WO disclosed
WO-2013033269-A1 BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS AND METHODS OF USING SAME COFERON, INC. (US) 2013-03-07 WO disclosed
WO-2013033270-A2 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME COFERON, INC. (US) 2013-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243322-A1 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME BRDT, BRD2, BRD4 BRD4 3/4885BRDT 1/4885BRD2 2/4885
US-20140243286-A1 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME BRDT, BRD4, BRD1 BRD4 2/4885BRDT 1/4885BRD2 5/4885
US-20230159554-A1 COMPOUND WITH ANTICANCER ACTIVITY TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC2 BRD4 2025/4885BRDT 1908/4885BRD2 3053/4885
US-20140243321-A1 BIOORTHOGONAL MONOMERS CAPABLE OF DIMERIZING AND TARGETING BROMODOMAINS, AND METHODS OF USING SAME BRDT, BRD4, BRD1 BRD4 2/4885BRDT 1/4885BRD2 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.