SCHEMBL14759134

SCHEMBL14759134

CCn1cc(CNCc2cnc(Oc3ccc4c(c3)CCC(c3ccccc3)O4)s2)c(C)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC8A1 P32418 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14759308 0.91 SLC8A1 (1.00) SLC8A1
SCHEMBL14759379 0.85 SLC8A1 (1.00) SLC8A1
SCHEMBL14759287 0.83 SLC8A1 (0.84) SLC8A1
SCHEMBL14759623 0.83 SLC8A1 (1.00) SLC8A1
SCHEMBL14759461 0.82 SLC8A1 (1.00) SLC8A1
SCHEMBL14759146 0.82 SLC8A1 (1.00) SLC8A1
SCHEMBL14759835 0.82 SLC8A1 (1.00) SLC8A1
SCHEMBL14759852 0.82 SLC8A1 (1.00) SLC8A1
SCHEMBL14759230 0.81 SLC8A1 (1.00) SLC8A1
SCHEMBL14759455 0.81 SLC8A1 (1.00) SLC8A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2755970-B1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2016-03-30 EP disclosed
EP-2567958-B1 Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals SANOFI SA (FR) 2014-10-29 EP disclosed
EP-2567958-A1 Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals SANOFI (FR) 2013-03-13 EP disclosed