SCHEMBL14759449

SCHEMBL14759449

CCOC(=O)C(C)NC(=O)c1cnc(Oc2ccc3c(c2)CC[C@@H](c2cccnc2)O3)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC8A1 P32418 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14759448 1.00 SLC8A1 (1.00) SLC8A1
SCHEMBL14759452 1.00 SLC8A1 (1.00) SLC8A1
SCHEMBL14759483 0.93 SLC8A1 (1.00) SLC8A1
SCHEMBL14759477 0.93 SLC8A1 (1.00) SLC8A1
SCHEMBL14759480 0.93 SLC8A1 (1.00) SLC8A1
SCHEMBL14759171 0.93 SLC8A1 (1.00) SLC8A1
SCHEMBL14759176 0.93 SLC8A1 (1.00) SLC8A1
SCHEMBL14759173 0.93 SLC8A1 (1.00) SLC8A1
SCHEMBL14759147 0.93 SLC8A1 (1.00) SLC8A1
SCHEMBL14759145 0.93 SLC8A1 (1.00) SLC8A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2755970-B1 SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS SANOFI SA (FR) 2016-03-30 EP disclosed
EP-2567958-B1 Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals SANOFI SA (FR) 2014-10-29 EP disclosed
EP-2567958-A1 Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals SANOFI (FR) 2013-03-13 EP disclosed