Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 19/20 | 0.67 |
| ▸ | PDE10A | Q9Y233 | 16/20 | 0.67 |
| ▸ | PDE6D | O43924 | 1/20 | 0.54 |
| ▸ | PDE6A | P16499 | 1/20 | 0.54 |
| ▸ | PDE6G | P18545 | 1/20 | 0.54 |
| ▸ | PDE6B | P35913 | 1/20 | 0.54 |
| ▸ | PDE6C | P51160 | 1/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14771509 | 0.88 | PDE2A (0.69) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14765074 | 0.82 | PDE2A (0.71) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL14765096 | 0.81 | PDE2A (1.00) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14765186 | 0.79 | PDE2A (0.72) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14765047 | 0.77 | PDE2A (0.74) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL14765035 | 0.75 | PDE2A (0.71) | PDE2APDE10APDE4DPDE11A | |
| SCHEMBL14361873 | 0.75 | PDE2A (0.83) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL14771474 | 0.75 | PDE2A (0.72) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL12502680 | 0.74 | PDE2A (1.00) | PDE2APDE10APDE4DPDE11AESR2 | |
| SCHEMBL12502893 | 0.73 | PDE2A (1.00) | PDE2APDE10APDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2013034758-A1 | SUBSTITUTED TRIAZOLOPYRAZINES AND USES THEREOF | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |