Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 19/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.66 |
| ▸ | PDE6D | O43924 | 4/20 | 0.66 |
| ▸ | PDE6A | P16499 | 4/20 | 0.66 |
| ▸ | PDE6G | P18545 | 4/20 | 0.66 |
| ▸ | PDE6B | P35913 | 4/20 | 0.66 |
| ▸ | PDE6C | P51160 | 4/20 | 0.66 |
| ▸ | PDE6H | Q13956 | 4/20 | 0.66 |
| ▸ | PDE4A | P27815 | 3/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.66 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16052553 | 0.85 | PDE10A (0.66) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL14764912 | 0.84 | PDE2A (0.83) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL14765186 | 0.83 | PDE2A (0.72) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL16052727 | 0.81 | PDE10A (0.51) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL12502680 | 0.78 | PDE2A (1.00) | PDE2APDE10APDE4DPDE11A | |
| SCHEMBL16053046 | 0.78 | PDE2A (0.70) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL16053384 | 0.77 | PDE2A (0.54) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL14764983 | 0.77 | PDE2A (0.67) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL14774006 | 0.76 | PDE2A (0.62) | PDE2APDE10APDE4DPDE6DPDE6A | |
| SCHEMBL14765176 | 0.76 | PDE2A (0.70) | PDE2APDE10APDE4DPDE6DPDE6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | claimed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |