Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | GAA | P10253 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.80 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2543291 | 0.89 | MAPT (1.00) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL3107523 | 0.89 | MAPT (1.00) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL3111183 | 0.89 | MAPT (1.00) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL23354985 | 0.87 | MAPT (0.61) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL20639894 | 0.87 | MAPT (0.61) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL16249928 | 0.86 | MAPT (0.78) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL6939980 | 0.85 | MAPT (0.73) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL12067678 | 0.85 | MAPT (0.77) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL9665148 | 0.85 | MAPT (0.77) | MAPTKDM4EGAALMNAALDH1A1 | |
| SCHEMBL14764652 | 0.85 | MAPT (0.80) | MAPTKDM4EGAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545666-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-02-10 | — | — | US | disclosed |
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-11-17 | — | — | US | disclosed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-02-07 | — | — | US | disclosed |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-9102664-B2 | Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED (IN) | 2015-08-11 | — | — | US | disclosed |
| US-9102664-B2 | Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED (IN) | 2015-08-11 | — | — | US | disclosed |
| US-20140343285-A1 | Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof | MSN LABORATORIES LIMITED (IN) | 2014-11-20 | — | — | US | disclosed |
| US-20140343285-A1 | Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof | MSN LABORATORIES LIMITED (IN) | 2014-11-20 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
| WO-2013042138-A2 | PROCESS FOR THE PREPARATION OF TRIAZOLE ANTIFUNGAL DRUG, ITS INTERMEDIATES AND POLYMORPHS THEREOF | MSN LABORATORIES LIMITED (IN) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013036866-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363672-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | MAPT 3556/4885KDM4E 2405/4885GAA 1408/4885 |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | MAPT 3556/4885KDM4E 2405/4885GAA 1408/4885 |
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | MAPT 3556/4885KDM4E 2405/4885GAA 1408/4885 |
| US-12545666-B2 | Itraconazole analogs and use thereof | SHH, SMO, GLI1 | MAPT 2130/4885KDM4E 3294/4885GAA 4299/4885 |
| US-20140343285-A1 | Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof | CYP3A4, CYP51A1, CYP1B1 | MAPT 1385/4885KDM4E 2621/4885GAA 505/4885 |
| US-11028078-B2 | Itraconazole analogs and use thereof | SHH, GLI1, KDR | MAPT 3556/4885KDM4E 2405/4885GAA 1408/4885 |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | SHH, GLI1, KDR | MAPT 3556/4885KDM4E 2405/4885GAA 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.