Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12725566 | 0.92 | BRAF (0.87) | BRAF | |
| SCHEMBL1593038 | 0.92 | BRAF (1.00) | BRAF | |
| SCHEMBL1593039 | 0.92 | BRAF (1.00) | BRAF | |
| SCHEMBL1593071 | 0.91 | BRAF (0.87) | BRAF | |
| SCHEMBL1593070 | 0.91 | BRAF (0.87) | BRAF | |
| SCHEMBL1593011 | 0.86 | BRAF (0.89) | BRAF | |
| SCHEMBL14765659 | 0.84 | BRAF (0.70) | BRAF | |
| SCHEMBL14765670 | 0.80 | BRAF (0.63) | BRAF | |
| SCHEMBL14765665 | 0.79 | BRAF (0.62) | BRAF | |
| SCHEMBL1593576 | 0.78 | BRAF (1.00) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394795-B2 | Pyrazole [3, 4-B] pyridine Raf inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-03-12 | — | — | US | disclosed |