Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.78 |
| ▸ | MAPK9 | P45984 | 17/20 | 0.78 |
| ▸ | MAPK10 | P53779 | 14/20 | 0.72 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14175827 | 1.00 | MAPK8 (0.78) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14175824 | 0.92 | MAPK8 (0.74) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14768066 | 0.92 | MAPK8 (0.74) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14768341 | 0.92 | MAPK8 (0.85) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14175832 | 0.92 | MAPK8 (0.79) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14175840 | 0.92 | MAPK8 (0.85) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14768101 | 0.90 | MAPK8 (0.75) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14175922 | 0.90 | MAPK8 (0.75) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL5102719 | 0.90 | MAPK8 (0.77) | MAPK8MAPK9MAPK10CDK1CDK4 | |
| SCHEMBL14175810 | 0.90 | MAPK8 (0.77) | MAPK8MAPK9MAPK10CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |