Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 20/20 | 0.73 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.72 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14175904 | 1.00 | MAPK8 (0.73) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14768249 | 0.88 | MAPK8 (0.73) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14175893 | 0.88 | MAPK8 (0.73) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14768072 | 0.87 | MAPK8 (0.73) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14175911 | 0.87 | MAPK8 (0.73) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14175848 | 0.87 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14768124 | 0.87 | MAPK8 (0.69) | MAPK8MAPK9MAPK10 | |
| SCHEMBL14193736 | 0.86 | MAPK8 (0.59) | MAPK8MAPK9MAPK10 | |
| SCHEMBL1163167 | 0.85 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 | |
| SCHEMBL6862985 | 0.85 | MAPK8 (1.00) | MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |