Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.31 |
| ▸ | TSHR | P16473 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12911786 | 0.98 | CYP2D6 (0.38) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL19194777 | 0.95 | CYP2D6 (0.39) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL24576857 | 0.95 | CYP2D6 (0.39) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL10254913 | 0.95 | CYP2D6 (0.42) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL19194778 | 0.93 | CYP2D6 (0.38) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL12911789 | 0.93 | CYP2D6 (0.41) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL12890875 | 0.90 | CYP2D6 (0.42) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL10111445 | 0.87 | CYP2D6 (0.46) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 | |
| SCHEMBL10111444 | 0.86 | CYP2D6 (0.39) | CYP2D6HRH3CYP1A2CYP2C9TSHR | |
| SCHEMBL7770721 | 0.85 | CYP2D6 (0.45) | CYP2D6HRH3CHRNA7CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |
| US-9682991-B2 | Tricyclic compounds for use as kinase inhibitors | FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2017-06-20 | — | — | US | disclosed |
| US-9682991-B2 | Tricyclic compounds for use as kinase inhibitors | FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2017-06-20 | — | — | US | disclosed |
| US-20130065881-A1 | Tricyclic Compounds for Use as Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (ES) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065881-A1 | Tricyclic Compounds for Use as Kinase Inhibitors | PIM1, PIM2, PIM3 | CYP2D6 1321/4885HRH3 2576/4885CHRNA7 4789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.