Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460440 | 0.84 | KDR (0.53) | CDK4CDK2SLC2A1EPHB4CDC7 | |
| SCHEMBL14045639 | 0.83 | EPHB4 (0.49) | CDK4CDK2SLC2A1EPHB4CDC7 | |
| SCHEMBL6643597 | 0.78 | IGF1R (0.59) | CDK4CDK2SLC2A1EPHB4CDC7 | |
| SCHEMBL582624 | 0.78 | EPHB4 (0.58) | CDK4CDK2SLC2A1EPHB4CDC7 | |
| SCHEMBL14634754 | 0.76 | CDK4 (0.60) | CDK4CDK2SLC2A1EPHB4CDC7 | |
| SCHEMBL14045638 | 0.76 | CDK4 (0.48) | CDK4CDK2SLC2A1EPHB4CDC7 | |
| SCHEMBL6642791 | 0.74 | IGF1R (0.71) | CDK4CDK2EPHB4CDC7EGFR | |
| SCHEMBL4882518 | 0.74 | SYK (0.50) | CDK2EGFRSYKKDRJAK3 | |
| SCHEMBL6979822 | 0.74 | SYK (0.41) | EGFRSYKKDRAURKA | |
| SCHEMBL6210596 | 0.73 | KCNH2 (0.47) | SYKKDRDYRK1ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130065890-A1 | PYRIMIDINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065890-A1 | PYRIMIDINE DERIVATIVES | TYMS, KDR, FLT4 | CDK4 22/4885CDK2 16/4885SLC2A1 2231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.