SCHEMBL14773138

C[C@@H]1CCOC2C(=O)[C@@]3(C)C4CC[C@H]5C(C)(C)[C@@H](O[C@@H](C=O)OCC=O)CC[C@@]56CC46CC[C@]3(C)[C@H]21

nearest known ligand 0.42

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	8/20	0.42

▸	PSEN2	P49810	8/20	0.42

▸	APH1B	Q8WW43	8/20	0.42

▸	NCSTN	Q92542	8/20	0.42

▸	APH1A	Q96BI3	8/20	0.42

▸	PSENEN	Q9NZ42	8/20	0.42

▸	APP	P05067	12/20	0.33

▸	CYP3A4	P08684	3/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL14773195	1.00	PSEN1 (0.42)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL12331078	0.82	PSEN1 (0.46)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14755870	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14753357	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14751590	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14751651	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14755378	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14753385	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14753715	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14768467	0.80	PSEN1 (0.67)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2013036665-A1	COMPOUNDS FOR USE IN TREATING NEURODEGENERATIVE DISORDERS, SYNTHESIS THEREOF, AND INTERMEDIATES THERETO	SATORI PHARMACEUTICALS, INC. (US)	2013-03-14	—	—	WO	disclosed