SCHEMBL14773604

COC(C[C@@H](C)[C@H]1C[C@H](O)[C@@]2(C)C3CCC4C(C)(C)[C@@H](OC(=O)N5CCOCC5)CC[C@@]45CC35CC[C@]12C)[C@H](OC(=O)N(C)C)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	PSEN1	P49768	17/20	0.47

▸	PSEN2	P49810	17/20	0.47

▸	APH1B	Q8WW43	17/20	0.47

▸	NCSTN	Q92542	17/20	0.47

▸	APH1A	Q96BI3	17/20	0.47

▸	PSENEN	Q9NZ42	17/20	0.47

▸	GPBAR1	Q8TDU6	1/20	0.36

▸	APP	P05067	1/20	0.34

▸	PTPN11	Q06124	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL14754645	1.00	PSEN1 (0.47)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14753314	0.94	PSEN1 (0.45)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL12332210	0.94	PSEN1 (0.45)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL12331534	0.92	PSEN1 (0.48)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14754662	0.92	PSEN1 (0.48)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL12331803	0.91	PSEN1 (0.47)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14753288	0.89	PSEN1 (0.42)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL14773550	0.89	PSEN1 (0.42)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL12233640	0.88	PSEN1 (0.42)	PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL12233470	0.87	PSEN1 (0.47)	PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2013036684-A1	COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS	SATORI PHARMACEUTICALS, INC (US)	2013-03-14	—	—	WO	disclosed