Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14775384 | 0.99 | ACKR3 (0.50) | ACKR3SLC6A2SLC6A4SLC6A3DRD1 | |
| Hydrochloric Acid SCHEMBL14775362 | 0.82 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3DRD1ALOX5 | |
| SCHEMBL27839317 | 0.79 | ACKR3 (0.44) | ACKR3SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL14775382 | 0.79 | SLC6A2 (0.75) | ACKR3SLC6A2SLC6A4SLC6A3DRD1 | |
| Hydrochloric Acid SCHEMBL27839440 | 0.79 | ACKR3 (0.44) | ACKR3SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL14775624 | 0.78 | SLC6A2 (0.73) | ACKR3SLC6A2SLC6A4SLC6A3DRD1 | |
| Hydrochloric Acid SCHEMBL14775055 | 0.78 | SLC6A2 (0.73) | ACKR3SLC6A2SLC6A4SLC6A3DRD1 | |
| Hydrochloric Acid SCHEMBL14775446 | 0.77 | SLC6A2 (0.72) | ACKR3SLC6A2SLC6A4SLC6A3DRD1 | |
| SCHEMBL14775368 | 0.76 | SLC6A2 (0.77) | ACKR3SLC6A2SLC6A4SLC6A3DRD1 | |
| SCHEMBL21912351 | 0.76 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3DRD1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570409-B1 | ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANT | SHANGHAI INST PHARM INDUSTRY (CN) | 2015-07-08 | — | — | EP | disclosed |
| EP-2570409-A1 | ARALKYL DIAMINE DERIVATIVES AND USES THEREOF AS ANTIDEPRESSANT | Shanghai Institute of Pharmaceutical Industry (CN) | 2013-03-20 | — | — | EP | disclosed |