Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aminosalicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.92 |
| ▸ | POLB | P06746 | 2/20 | 0.92 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminosalicylic Acid SCHEMBL30724149 | 1.00 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL688206 | 0.96 | KDM4E (1.00) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL31065282 | 0.96 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL11795055 | 0.96 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL31598403 | 0.96 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL29379024 | 0.96 | KDM4E (1.00) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL11788856 | 0.96 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL1457932 | 0.96 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL1047421 | 0.96 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 | |
| Aminosalicylic Acid SCHEMBL191239 | 0.96 | KDM4E (0.92) | KDM4ETDP1POLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10876082-B2 | Surface treatment composition, method for producing surface treatment composition, surface treatment method, and method for producing semiconductor substrate | FUJIMI INCORPORATED (JP) | 2020-12-29 | — | — | US | disclosed |
| US-20190085270-A1 | SURFACE TREATMENT COMPOSITION, METHOD FOR PRODUCING SURFACE TREATMENT COMPOSITION, SURFACE TREATMENT METHOD, AND METHOD FOR PRODUCING SEMICONDUCTOR SUBSTRATE | FUJIMI INCORPORATED (JP) | 2019-03-21 | — | — | US | disclosed |
| CN-101538217-B | Novel synthesis method of 2-ethoxy-4-amino-5-chlorobenzoic acid and intermediate thereof | CHENGDU HONGDA PHARMACEUTICAL CO LTD | 2015-04-15 | — | — | CN | disclosed |
| CN-103396334-A | New synthesis method of 2-ethoxy-4-amino-5-chlorobenzoic acid and intermediate thereof | CHENGDU HONGDA PHARMACEUTICAL CO LTD | 2013-11-20 | — | — | CN | disclosed |
| EP-1292338-B1 | STABILISER FOR RADIOPHARMACEUTICALS | GE HEALTHCARE LTD (GB) | 2012-09-19 | — | — | EP | disclosed |
| US-7914768-B2 | Increase shelf life with a mixture of stabilizers, comprising an amino-substituted aromatic carboxylic acid and a diphosphonic acids; radioactive metal with amine oxime complexes; nondegrading | GE HEALTHCARE LIMITED (GB) | 2011-03-29 | — | — | US | disclosed |
| CN-101538217-A | Novel synthesis method of 2-ethoxy-4-amino-5-chlorobenzoic acid and intermediate thereof | CHENGDU KANGHONG PHARMACEUTICA | 2009-09-23 | — | — | CN | disclosed |
| US-7572303-B2 | A symmetrical dialkyl carbonate, a metal, borong, silicon, or group 7 compound, a hydrogen or hydrocarbon-based fuel, an oxidizer, and a metallic cocatalyst; minimized hydrolysis; improved combustion and storage stability | OCTANE INTERNATIONAL, LTD. (US) | 2009-08-11 | — | — | US | disclosed |
| EP-0954558-B1 | FUEL COMPOSITIONS EXHIBITING IMPROVED FUEL STABILITY | ORR WILLIAM C (US) | 2006-06-14 | — | — | EP | disclosed |
| US-20050063902-A1 | Stabiliser for radiopharmaceuticals | GE HEALTHCARE LIMITED (GB) | 2005-03-24 | — | — | US | disclosed |
| US-20050044778-A1 | Fuel compositions employing catalyst combustion structure | OCTANE INTERNATIONAL, LTD. | 2005-03-03 | — | — | US | disclosed |
| US-20040237384-A1 | Fuel compositions exhibiting improved fuel stability | OCTANE INTERNATIONAL, LTD. | 2004-12-02 | — | — | US | disclosed |
| US-6652608-B1 | Fuel compositions exhibiting improved fuel stability | OCTANE INTERNATIONAL, LTD. | 2003-11-25 | — | — | US | disclosed |
| EP-1292338-A2 | STABILISER FOR RADIOPHARMACEUTICALS | GE Healthcare Limited (GB) | 2003-03-19 | — | — | EP | disclosed |
| WO-2001097862-A2 | STABILISER FOR RADIOPHARMACEUTICALS | AMERSHAM PLC (GB) | 2001-12-27 | — | — | WO | disclosed |
| EP-1051461-A2 | FUEL COMPOSITIONS EMPLOYING CATALYST COMBUSTION STRUCTURE | ORR, William C. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999066009-A2 | FUEL COMPOSITIONS EMPLOYING CATALYST COMBUSTION STRUCTURE | ORR WILLIAM C (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0954558-A1 | FUEL COMPOSITIONS EXHIBITING IMPROVED FUEL STABILITY | ORR, William C. (US) | 1999-11-10 | — | — | EP | disclosed |
| WO-1998026028-A1 | FUEL COMPOSITIONS EXHIBITING IMPROVED FUEL STABILITY | ORR WILLIAM C (US) | 1998-06-18 | — | — | WO | disclosed |
| US-4036951-A | SUNSCREEN AGENTS | SYNERGISTICS, INC. (US) | 1977-07-19 | — | — | US | disclosed |