Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853713 | 0.93 | PDE7A (0.71) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL853816 | 0.92 | PDE7A (0.72) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL14775750 | 0.91 | PDE7A (0.62) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL853253 | 0.90 | PDE7A (0.68) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL853198 | 0.90 | MAPT (0.60) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL852726 | 0.89 | MAPT (0.66) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL853087 | 0.85 | PDE7A (0.71) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL852915 | 0.85 | MAPT (0.63) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL853907 | 0.84 | PDE7A (0.73) | MAPTTP53PDE7APOLBNPC1 | |
| SCHEMBL853869 | 0.84 | PDE7A (0.71) | MAPTTP53PDE7APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1775298-B1 | THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2013-03-20 | — | — | EP | claimed |