Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.73 |
| ▸ | TP53 | P04637 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL854024 | 0.91 | MAPT (0.72) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL14775914 | 0.91 | MAPT (0.72) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL855145 | 0.91 | MAPT (0.72) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL854849 | 0.90 | MAPT (0.71) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL853289 | 0.90 | MAPT (0.71) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL853067 | 0.90 | MAPT (0.69) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL853735 | 0.90 | PDE7A (0.70) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL853800 | 0.88 | MAPT (0.85) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL853125 | 0.86 | PDE7A (0.71) | MAPTTP53POLBHPGDALDH1A1 | |
| SCHEMBL854483 | 0.86 | MAPT (0.82) | MAPTTP53POLBHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1775298-B1 | THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2013-03-20 | — | — | EP | claimed |