Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | HPGD | P15428 | 8/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852846 | 0.85 | NPC1 (0.76) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL14775601 | 0.84 | HPGD (0.68) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL14775653 | 0.83 | PDE7A (0.78) | PDE7A | |
| SCHEMBL853038 | 0.77 | HTT (0.96) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL853741 | 0.76 | HTT (0.86) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL852722 | 0.76 | HTT (0.81) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL854345 | 0.76 | KDM4E (0.70) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL853828 | 0.76 | HTT (0.73) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL852979 | 0.76 | HTT (0.71) | ALDH1A1HPGDKDM4ENPSR1LMNA | |
| SCHEMBL853404 | 0.76 | HTT (0.84) | ALDH1A1HPGDKDM4ENPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1775298-B1 | THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2013-03-20 | — | — | EP | claimed |