Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853627 | 0.91 | HTT (0.55) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL853080 | 0.86 | KDM4E (0.66) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL854765 | 0.83 | PDE7A (0.68) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL853856 | 0.81 | PDE7A (0.67) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL853174 | 0.81 | PDE7A (0.67) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL14775819 | 0.81 | PDE7A (0.76) | PDE7A | |
| SCHEMBL855397 | 0.80 | KDM4E (0.65) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL852712 | 0.80 | KDM4E (0.65) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL851718 | 0.80 | PDE7A (0.56) | HTTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL854432 | 0.80 | PDE7A (0.68) | HTTNPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1775298-B1 | THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY | DAIICHI SANKYO CO LTD (JP) | 2013-03-20 | — | — | EP | claimed |