Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2684544 | 0.93 | KCNH2 (0.76) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2684689 | 0.89 | HDAC1 (0.69) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL4796287 | 0.88 | HDAC1 (0.66) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL14775996 | 0.87 | HDAC1 (0.65) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL4518876 | 0.87 | KCNH2 (0.82) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL4309845 | 0.86 | KCNH2 (0.80) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL14775938 | 0.85 | KCNH2 (0.66) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL2685880 | 0.85 | KCNH2 (0.67) | KCNH2HDAC1HDAC2HDAC3 | |
| SCHEMBL2685292 | 0.84 | HDAC1 (0.70) | KCNH2HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL8239728 | 0.82 | HDAC1 (0.74) | KCNH2HDAC1HDAC2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991226-B1 | INHIBITORS OF HISTONE DEACETYLASE | MERCK SHARP & DOHME (US) | 2013-03-20 | — | — | EP | claimed |