SCHEMBL14780845

SCHEMBL14780845

O=C(Nc1cc(Cl)c(O)c(CI)c1)c1cc(NC2CCCCC2)ncn1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 20/20 0.80
S1PR5 Q9H228 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2860414 0.90 S1PR1 (1.00) S1PR1S1PR5
SCHEMBL13236370 0.85 S1PR1 (0.85) S1PR1S1PR5
SCHEMBL13216675 0.82 S1PR1 (0.81) S1PR1S1PR5
SCHEMBL3036431 0.80 S1PR1 (1.00) S1PR1S1PR5
SCHEMBL3034436 0.77 S1PR1 (1.00) S1PR1S1PR5
SCHEMBL3029287 0.76 S1PR1 (1.00) S1PR1S1PR5
SCHEMBL13216676 0.76 S1PR1 (0.80) S1PR1S1PR5
SCHEMBL2859725 0.75 S1PR1 (1.00) S1PR1S1PR5
SCHEMBL2870294 0.75 S1PR1 (1.00) S1PR1S1PR5
SCHEMBL3231580 0.74 S1PR1 (0.80) S1PR1S1PR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8399448-B2 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis MERCK SERONO SA (CH) 2013-03-19 US disclosed