Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19260199 | 0.78 | CYP1A2 (0.71) | CYP1A1CYP1A2CYP1B1ALDH1A1CYP2A6 | |
| SCHEMBL1666787 | 0.77 | CYP1A1 (0.52) | CYP1A1CYP1A2CYP1B1MAPTALDH1A1 | |
| SCHEMBL19497056 | 0.77 | CYP1A2 (0.56) | CYP1A1CYP1A2CYP1B1KDM4EALDH1A1 | |
| SCHEMBL29946581 | 0.75 | CYP1A2 (0.52) | CYP1A1CYP1A2CYP1B1TDP1 | |
| SCHEMBL22750625 | 0.75 | CYP1A2 (0.52) | CYP1A1CYP1A2CYP1B1TDP1 | |
| SCHEMBL14790477 | 0.74 | CYP2A6 (0.38) | CYP1A1CYP1A2CYP1B1MAPTKDM4E | |
| SCHEMBL2344274 | 0.74 | CYP2A6 (0.50) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL744467 | 0.74 | CYP2A6 (0.50) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL4769651 | 0.74 | GRM5 (0.47) | CYP1A1CYP1A2CYP1B1ALDH1A1GRM5 | |
| SCHEMBL192166 | 0.74 | CYP2A6 (0.77) | CYP1A2MAPTKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR5 | CYP1A1 4540/4885CYP1A2 4548/4885CYP1B1 4845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.