Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.62 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.62 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 3/20 | 0.60 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | IDE | P14735 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13185104 | 0.97 | TDP1 (0.58) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL26902897 | 0.96 | TDP1 (0.62) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23334534 | 0.92 | TDP1 (0.68) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL1300276 | 0.92 | TDP1 (0.68) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL16123471 | 0.92 | TDP1 (0.68) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL15672766 | 0.91 | F2 (0.66) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL18972051 | 0.91 | F2 (0.66) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL22507546 | 0.91 | F2 (0.66) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23652847 | 0.91 | F2 (0.63) | TDP1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL19176506 | 0.91 | F2 (0.66) | TDP1F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072469-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2013-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072469-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | TDP1 2415/4885F2 625/4885PRSS1 2473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.