Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 9/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.46 |
| ▸ | KDR | P35968 | 9/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384401 | 0.76 | PDGFRB (0.67) | PDGFRBFGFR1KDRCHEK1FLT1 | |
| SCHEMBL15911026 | 0.75 | FGFR1 (0.67) | PDGFRBFGFR1KDRCHEK1FLT1 | |
| SCHEMBL3383803 | 0.75 | CHEK1 (0.77) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL13041411 | 0.75 | CHEK1 (0.77) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL13077925 | 0.75 | CHEK1 (0.77) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL3381507 | 0.74 | PDGFRB (0.61) | PDGFRBFGFR1KDRCHEK1FLT1 | |
| SCHEMBL14795799 | 0.71 | FGFR1 (0.52) | PDGFRBFGFR1KDRCHEK1FLT1 | |
| SCHEMBL14795676 | 0.71 | KDR (0.47) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL14796081 | 0.71 | CHEK1 (0.47) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL14796247 | 0.70 | CHEK1 (0.75) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |