Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.67 |
| ▸ | PRKCG | P05129 | 3/20 | 0.67 |
| ▸ | PRKCB | P05771 | 3/20 | 0.67 |
| ▸ | PRKCA | P17252 | 3/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.67 |
| ▸ | PRKCH | P24723 | 3/20 | 0.67 |
| ▸ | CDK2 | P24941 | 3/20 | 0.67 |
| ▸ | PRKCI | P41743 | 3/20 | 0.67 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.67 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.67 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.67 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15910767 | 0.94 | CHEK1 (0.75) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL15910750 | 0.93 | CHEK1 (0.79) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL6387344 | 0.89 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3381001 | 0.89 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3381730 | 0.89 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3381807 | 0.89 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3382255 | 0.89 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3379993 | 0.87 | CHEK1 (0.83) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3384695 | 0.87 | CHEK1 (1.00) | CHEK1PRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL3383642 | 0.87 | CHEK1 (0.83) | CHEK1PRKD3PRKCGPRKCBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |