Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 14/20 | 0.53 |
| ▸ | KDR | P35968 | 14/20 | 0.53 |
| ▸ | FLT1 | P17948 | 9/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795575 | 0.84 | FGFR1 (0.54) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3384436 | 0.81 | FGFR1 (0.70) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3383616 | 0.78 | FGFR1 (0.64) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3383500 | 0.77 | FGFR1 (0.64) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3382790 | 0.77 | FGFR1 (0.69) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3384784 | 0.76 | FGFR1 (0.87) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3381227 | 0.76 | FGFR1 (0.85) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL15910950 | 0.75 | PDGFRB (0.48) | FGFR1PDGFRBKDR | |
| SCHEMBL3381125 | 0.75 | FGFR1 (0.68) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3383594 | 0.75 | FGFR1 (0.55) | FGFR1PDGFRBKDRFLT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |