Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 14/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | FLT1 | P17948 | 6/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | TYMS | P04818 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAPDH | P04406 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14795367 | 0.86 | FGFR1 (0.54) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3378283 | 0.80 | FGFR1 (0.63) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL14795440 | 0.80 | FGFR1 (0.54) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL1052022 | 0.74 | FGFR1 (0.66) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL1055142 | 0.74 | FGFR1 (0.66) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL14796657 | 0.73 | FGFR1 (0.62) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL14795940 | 0.73 | FGFR1 (0.66) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3918718 | 0.72 | NPC1 (0.83) | KDM4ENPC1ALDH1A1PKMRAB9A | |
| SCHEMBL15910561 | 0.71 | FGFR1 (0.58) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL15911026 | 0.70 | FGFR1 (0.67) | FGFR1PDGFRBKDRFLT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| EP-2573079-A2 | Benzimidazole quinolinones and uses thereof | Novartis Vaccines and Diagnostics, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |