Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | TERT | O14746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL14806851 | 1.00 | TSHR (0.40) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL27976875 | 0.99 | TSHR (0.41) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL27976881 | 0.99 | TSHR (0.41) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL14806865 | 0.98 | TSHR (0.41) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| Zinc Ion SCHEMBL27976882 | 0.97 | TSHR (0.41) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL584884 | 0.92 | TSHR (0.47) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL12057431 | 0.89 | TSHR (0.41) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL584953 | 0.88 | CYP1A2 (0.40) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL6843058 | 0.87 | CYP1A2 (0.48) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL12668273 | 0.85 | TSHR (0.41) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2759546-B1 | METALLOPORPHYRIN COMPLEX, MANUFACTURING PROCESS THEREFOR AND ITS USE AS CARBON DIOXIDE FIXATION CATALYST, AS WELL AS PROCESS FOR MANUFACTURING CYCLIC CARBONATE | NAT UNIV CORPORATION OKAYAMA UNIV (JP) | 2018-03-21 | — | — | EP | disclosed |
| US-9211534-B2 | Metalloporphyrin complex, manufacturing process therefor and carbon dioxide fixation catalyst therefrom, as well as process for manufacturing cyclic carbonate | NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (JP) | 2015-12-15 | — | — | US | disclosed |
| US-20140228561-A1 | METALLOPORPHYRIN COMPLEX, MANUFACTURING PROCESS THEREFOR AND CARBON DIOXIDE FIXATION CATALYST THEREFROM, AS WELL AS PROCESS FOR MANUFACTURING CYCLIC CARBONATE | NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (JP) | 2014-08-14 | — | — | US | disclosed |
| EP-2759546-A1 | METAL PORPHYRIN COMPLEX, METHOD FOR PRODUCING SAME, CARBON DIOXIDE IMMOBILIZATION CATALYST COMPRISING SAME, AND METHOD FOR PRODUCING CYCLIC CARBONIC ACID ESTER. | National University Corporation Okayama University (JP) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013042695-A1 | METAL PORPHYRIN COMPLEX, METHOD FOR PRODUCING SAME, CARBON DIOXIDE IMMOBILIZATION CATALYST COMPRISING SAME, AND METHOD FOR PRODUCING CYCLIC CARBONIC ACID ESTER. | 国立大学法人岡山大学 (JP) | 2013-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228561-A1 | METALLOPORPHYRIN COMPLEX, MANUFACTURING PROCESS THEREFOR AND CARBON DIOXIDE FIXATION CATALYST THEREFROM, AS WELL AS PROCESS FOR MANUFACTURING CYCLIC CARBONATE | CYP4F11, CYP4F2, CYP4F12 | ADRB2 4815/4885CHRM2 3225/4885ADRB1 4858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.