Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.50 |
| ▸ | CTSD | P07339 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CTSE | P14091 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15717306 | 0.85 | BACE1 (0.49) | BACE1CTSDKCNH2 | |
| SCHEMBL2370573 | 0.85 | BACE1 (0.54) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL2370746 | 0.84 | BACE1 (0.72) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL14807949 | 0.83 | BACE1 (0.52) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL16109481 | 0.82 | BACE1 (0.68) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL16109631 | 0.82 | BACE1 (0.68) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL14808412 | 0.81 | BACE1 (0.74) | BACE1KCNH2 | |
| SCHEMBL15717046 | 0.78 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL14808434 | 0.78 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL14808534 | 0.78 | BACE1 (0.76) | BACE1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758406-A1 | AMINO-OXAZINES AND AMINO-DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013044092-A1 | AMINO-OXAZINES AND AMINO-DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2013-03-28 | — | — | WO | disclosed |