Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 19/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14810696 | 0.86 | EIF4E (0.74) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL14811709 | 0.83 | EIF4E (0.67) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL14810560 | 0.82 | EIF4E (0.61) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL14810817 | 0.82 | EIF4E (0.78) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL14810866 | 0.81 | EIF4E (0.61) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL14797324 | 0.80 | EIF4E (1.00) | EIF4E | |
| SCHEMBL14797083 | 0.80 | EIF4E (1.00) | EIF4E | |
| SCHEMBL14810940 | 0.80 | EIF4E (0.77) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL14797291 | 0.79 | EIF4E (0.73) | EIF4EKDM4EMEN1NPC1RAB9A | |
| SCHEMBL14820479 | 0.79 | EIF4E (0.85) | EIF4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758380-A1 | BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013041468-A1 | BENZOIC ACID DERIVATIVES AS EIF4E INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-03-28 | — | — | WO | disclosed |