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SCHEMBL14814014

SCHEMBL14814014

Cc1n[nH]c2nc(-c3ccc(O)c(F)c3)cc(C(=O)N3CCC4(CC3)CNC4)c12

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ PARP1 P09874 6/20 0.39
▸ PIK3CA P42336 3/20 0.38
▸ MTOR P42345 3/20 0.38
▸ ESR1 P03372 1/20 0.37
▸ ESR2 Q92731 1/20 0.37
▸ KDM1A O60341 2/20 0.36
▸ NAMPT P43490 1/20 0.34
▸ GSK3B P49841 1/20 0.34
▸ ATR Q13535 1/20 0.34
▸ ALK Q9UM73 1/20 0.33
▸ JAK2 O60674 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14813574 0.94 PARP1 (0.46) PARP1PIK3CAMTORESR1ESR2
SCHEMBL14813798 0.91 PARP1 (0.43) PARP1PIK3CAMTORESR1ESR2
SCHEMBL14813520 0.89 PARP1 (0.42) PARP1PIK3CAMTORESR1ESR2
SCHEMBL14813865 0.88 ATR (0.41) PARP1ESR1ESR2GSK3BATR
SCHEMBL14813483 0.88 KDM1A (0.38) PARP1KDM1ANAMPTGSK3BNPC1
SCHEMBL14813637 0.86 ESR1 (0.41) PARP1PIK3CAMTORESR1ESR2
SCHEMBL14827067 0.86 PIK3CA (0.43) PARP1PIK3CAMTORESR1ESR2
SCHEMBL14813982 0.86 NAMPT (0.40) PARP1ESR1ESR2KDM1ANAMPT
SCHEMBL14813587 0.86 PARP1 (0.40) PARP1PIK3CAMTORESR1ESR2
SCHEMBL14813835 0.86 KDM1A (0.41) PARP1ESR1ESR2KDM1AATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2760862-B1 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS SANOFI SA (FR) 2015-10-21 — — EP disclosed
EP-2760862-B1 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS SANOFI SA (FR) 2015-10-21 — — EP disclosed
WO-2013045413-A1 6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS SANOFI (FR) 2013-04-04 — — WO disclosed
US-20130085128-A1 6-(4-Hydroxy-phenyl)-3-alkyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors SANOFI (FR) 2013-04-04 — — US disclosed
US-20130085128-A1 6-(4-Hydroxy-phenyl)-3-alkyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors SANOFI (FR) 2013-04-04 — — US disclosed
US-20130085128-A1 6-(4-Hydroxy-phenyl)-3-alkyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors SANOFI (FR) 2013-04-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130085128-A1 6-(4-Hydroxy-phenyl)-3-alkyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors MAP3K1, MAP3K6, MAP4K2 PARP1 1593/4885PIK3CA 27/4885MTOR 162/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.