Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GLS | O94925 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196660 | 0.83 | ACKR3 (0.64) | ACKR3POLBNPC1RAB9AHPGD | |
| SCHEMBL12093452 | 0.80 | NPSR1 (0.61) | ACKR3POLBNPC1RAB9AHPGD | |
| SCHEMBL12156865 | 0.77 | ACKR3 (0.52) | ACKR3GLS | |
| SCHEMBL6395379 | 0.76 | ACKR3 (0.51) | ACKR3GLSCHRM3 | |
| SCHEMBL27257877 | 0.74 | ACKR3 (0.56) | ACKR3GLS | |
| SCHEMBL14198241 | 0.74 | ACKR3 (0.53) | ACKR3NPC1RAB9AHPGDCHRM3 | |
| SCHEMBL4185887 | 0.74 | ACKR3 (0.42) | ACKR3NPC1RAB9AGLSCHRM3 | |
| SCHEMBL13118285 | 0.74 | ACKR3 (0.61) | ACKR3CHRM3 | |
| SCHEMBL13162038 | 0.73 | ACKR3 (0.55) | ACKR3NPC1RAB9A | |
| SCHEMBL49464 | 0.73 | ACKR3 (0.51) | ACKR3CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802636-B1 | PI3 KINASES INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2013-03-27 | — | — | EP | disclosed |